Pdf as an innovative extension of electrospinning, coaxial electrospinning could. Fibers and particles fabricated by coaxial electrospinning have many applications. Single, coaxial, triaxial and multinozzle spinnerets. A logical next step is the inclusion of certain molecules and compounds to accelerate or increase the efficacy of tissue regeneration. The use of electrospun nanofibers in drug delivery has increased rapidly over recent years due to their valuable properties, which include a large surface area, high porosity, small pore size, superior mechanical properties, and ease of surface modification. Industrial upscaling of electrospinning and applications. Guided tissue regeneration is a standard surgical treatment for periodontal regeneration. Coaxial nozzle, where the nozzle comprises of an inner and outer orifice, is often associated with electrospinning coreshell fibers. Today, with substantial global demand from patients suffering from wounds and burns, the wound care sector has gained great deal of interest in. Aqueousbased coaxial electrospinning of genetically engineered. Steckl1 1department of electrical and computer engineer ing, university of cincinnati, cincinnati, oh, 45221 2department of surgery, university of cincinnati, cincinnati, oh, 45267 abstract we have investigated coaxial electrospinning to produce coresheath fibers for tissue.
With the rapid advancement of regenerative medicine technologies, there is an urgent need for the development of new, cellfriendly techniques for obtaining nanofibersthe raw material for an artificial extracellular matrix production. A stainless steel roller was used as collecting device. If polymer solution with a high concentration can be electrospun into ultrafine fibers, it would inevitably improve the capability of electrospinning and broaden the. Coaxial electrospun freestanding and mechanically stable. A series of analyses were undertaken to characterize. Rutledge1 1 department of chemical engineering, massachusetts institute of technology, cambridge, ma 029 2 department of chemical and materials engineering, california state polytechnic university, pomona, pomona, ca 91768.
The distance between the electrospinning nozzle and roller was 18 cm with a high voltage of 16 kv. Using a mixed solvent of ethanol and n,ndimethylacetamide as a sheath fluid, the electrospinning of a codissolving solution of diclofenac sodium ds and eudragit l100 el100 could run smoothly and continuously without any clogging. Previously, most of the electrospinning experiments have been carried out using singleneedle arrangements. Without question, the construction of tissue engineering scaffolds and the selection of the scaffold material. We investigated the structure and properties of pcl10 nanofibers, pcl5pcl10 coreshell type nanofibers, as well as pcl5pclag nanofibres prepared by. A common syringe pump controlled the flow rate of the two polymer solutions. Electrospinning requires a highvoltage power supply, a syringe pump, a polymer solution to be spun, and a grounded collection surface. Pdf coaxial electrospun nanostructures and their applications. Photocatalytic self cleaning textile fibers by coaxial electrospinning n. Electrospinning has been used extensively to synthesize nanofibers for various applications 4,6,1012 because it allows the precise control over the composition, structure, and mechanical properties of the resulting biomaterial.
Electrospinning has emerged as one of the potential techniques for producing nanofibers. The accurate prediction and manipulation of nanoscale product sizes is a major challenge in material processing. Pdf blend electrospinning, coaxial electrospinning, and emulsion. The coaxial electrospinning nozzle was a stainless steel nozzle with outer and inner diameter of 1.
Because of this propriety, users of the electrospinning systems prefer to start with smallscale laboratory experiences and scaleup subsequently once succeeded in the researches. Antioxidant, antibacterialantifungal nanostructures for. Electrospinning is the most commercially successful process for the production of nanofibers and rising demand is driving research and development in this field. The development of this method of encapsulation could be very relevant in food items, pharmaceuticals, textile industry, controlled. Production of coreshell fibers by electrospinning from a free surface keith m. A study of free surface electrospinning process to enhance. Versatile coresheath biofibers using coaxial electrospinning daewoo han1, steven t. The outer liquid of a twoliquid coaxial electrified jet is gelled before the onset of natural instabilities to yield hollow nanofibers. Pdf on jan 1, 2018, matej buzgo and others published blend electrospinning, coaxial electrospinning, and emulsion electrospinning techniques find, read and cite all the research you need on. The sulfadiazine or sulfadiazine modified chitosan nanoparticles loosely attached at the surface of the nanofibers, could provide a. Structure and properties of slowresorbing nanofibers. Electrospinning is a fiber production method which uses electric force to draw charged threads of polymer solutions or polymer melts up to fiber diameters in the order of some hundred nanometers. The capillary, through which the inner fluid is pumped, is positioned such that it runs coaxially inside the.
Us20100297906a1 methods for electrospinning hydrophobic. Steckl, nanoelectronics laboratory, department of electrical and computer engineering, and department of chemical and materials engineering, university of cincinnati, cincinnati, ohio 45221. These techniques include free surface electrospinning with 1st. Coaxial electrospinning of fluorescein isothiocyanateconjugated bovine serum. Coaxial electrospinning is an effective method for the preparation of hollow nanofibers and tissue engineering scaffolds, and the core and shell materials can be selected judiciously to meet the requirements for various applications. Coaxial electrospinning an overview sciencedirect topics. Biodegradable coreshell fibers by coaxial electrospinning. Study on the various types of needle based and needleless. A modified coaxial electrospinning for preparing fibers from a high. However, the coaxial nozzle design has many other uses in electrospinning and the production of fibers. Coaxial electrospinning provides the flexible and facilitate method to construct and fabricate diversiform nano or micro encapsulation materials and coreshell nano or micro devices. Electrospinning equipments nanofiber machines inovenso.
A modified free surface coaxial electrospinning setup was developed figs. A cellfree nanofiber composite scaffold regenerated. Coaxial electrospinning differs significantly from emulsioncentered methods in that it generates coresheath fibers by physical separation through the utilization of two electrospinning tips and two solutions. Putting electrospun nanofibers to work for biomedical research. Electrically forced coaxial nanojets for onestep hollow. As an evolution of conventional electrospinning, coaxial electrospinning became popular soon after its debut as a novel way to develop nanofibers with special structures, such as coreshell and hollow interior. Elastic fibers are a fundamental requirement for tissue. Coaxial nanofibers from polycaprolactone polyvinyl. Us20180226582a1 us15891,178 us201815891178a us2018226582a1 us 20180226582 a1 us20180226582 a1 us 20180226582a1 us 201815891178 a us201815891178 a us 201815891178a us 2018226582 a1 us2018226582 a1 us 2018226582a1 authority us united states prior art keywords coaxial nanocomposite wt polymer nm prior art date 20170207 legal status the legal status is an. Steckl, nanoelectronics laboratory, department of electrical engineering and computing systems, university of cincinnati, cincinnati, ohio 45221, united states department of chemistry, university of cincinnati. Coaxial electrospinning coes schematic diagram of a coaxial electrospinning apparatus and a coaxial electrospinneret are shown in fig. For the purpose of producing a novel guided tissue regeneration membrane with antibacterial activity and osteogenesis, coaxial electrospinning was utilized to manufacture coreshell structure fiber mats. In this investigation, two process characteristics were explored during the modified coaxial electrospinning of zein, with the aim of understanding how this impacts the products formed. Electrospinning is a useful and efficient technique to produce ultrafine.
Nadetech ndes lab electrospinning unit is a completely automatized. Coaxial needles for electrospinning linari biomedical. Coaxial electrospinning formation of complex polymer fibers and. Manufacturing of bioreactive nanofibers for bioremediation.
Coaxial electrospinning for nanostructured advanced. Production of coreshell fibers by electrospinning from a. The process does not require the use of coagulation chemistry or high temperatures to. Methods for electrospinning a hydrophobic coaxial fiber into a superhydrophobic coaxial fiber mat can include providing an electrospinning coaxial nozzle comprising a core outlet coaxial with a sheath outlet, ejecting an electrospinnable core solution from the core outlet of the electrospinning coaxial nozzle, ejecting a hydrophobic sheath solution from the sheath outlet of the electrospinning. Coaxial electrospinning and sustained release properties. Electrohydrodynamic ehd compound jets, with diameters in the micro and nanometric size range, from conical menisci of two coflowing liquids, is a consolidated platform for the production of nanofibers with inner structure, in a process socalled coaxial electrospinning or coelectrospinning. Coaxial electrospinning with agno 3 solution as sheath fluid not only facilitates the electrospinning process, providing nanofibers with reduced diameters, but also allows functionalization of the nanofibers through coating with functional ingredients, effectively ensuring that the active antibacterial component is on the surface of the material, which leads to enhanced activity. Recently, a coaxial electrospinning process has been used to fabricate new nanostructures with advanced performance, but intricate and delicate process conditions hinder. Electrospun nanofibers for drug delivery systems sigma.
They are also grateful to the chinese academy of sciences. In this study, we evaluated the influence of various processing parameters such as sheath polymer concentration, core polymer concentration and molecular weight, and salt. Solutions of two biodegradable polymers, that is, polydllactic acid pdlla and poly3hydroxy butyrate phb, were individually delivered to the inner and outer channel of a coaxial tube spinneret for electrospinning to prepare core. Electrospun nanofibers offers systematic and comprehensive coverage for academic researchers, industry professionals, and postgraduate students working in the field of fiber science. Coaxial electrospinning is an innovatively extended form of electrospinning, which uses two concentrically aligned capillaries to enforce the. Control of physical properties of carbon nanofibers obtained from coaxial electrospinning of pmma and. Oct2010 2 linari engineering solves the problem of stable geometry for coaxial electrospinning with a stainless steel solution able to cut setup and cleaning time with a quick dismountable assembly.
Coaxial electrospinning is an extended form of electrospinning for the synthesis of composite nanofibers for efficient gene delivery because of the unique structure of coaxial electrospun nanofibers. The characteristics studied were the spreading angle at the unstable region. Coaxial electrospinning we work mainly with coaxial electrospining 2, in which one fluid is spun inside another. This is achieved by inserting a thin flexible capillary into the tube through which the main spinning solution is pumped. The electrospinning apparatus consists of a coaxial spinneret and a syringe pump new era pump systems ne, farmingdale, ny mounted on a wood stand. Coaxial electrospinning is also useful for the encapsulation of nonspinnable materials such as nanoparticles or conjugated polymers exhibiting a poor thermoplastic behavior, 114 enzymes, protein, and cells. Electrospinning shares characteristics of both electrospraying and conventional solution dry spinning of fibers. Everyday new publications show different applications for the electrospun nanofibers. Pdf superhydrophobic and oleophobic fibers by coaxial. Solutions of two biodegradable polymers, that is, polydllactic acid pdlla and poly3hydroxy butyrate phb, were individually delivered to the inner and outer channel of a coaxialtube spinneret for electrospinning to prepare core. A multifunctional coaxial fiber membrane loaded with dual. Electrospinning is still a new and mysterious field of research with nanofibers. Preparation by coaxial electrospinning and characterization of membranes releasing.
In recent years, there has been an increasing interest in. Pdf blend electrospinning, coaxial electrospinning, and. However, the low fluid throughput in singleneedle spinning has limited the industrial use of singleneedle schemes. Polymers free fulltext the relationships between the. Lei jiang for great help on technology and knowledge. One of the most relevant techniques to fabricate polymer nanofibers with unique coresheath or hollow structures micronanocapsules, hollow spheres, hollow fibers and coaxial fibers is the recently discovered coaxial electrospinning and electrospray technique. Photocatalytic self cleaning textile fibers by coaxial.
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